![]() Additional effective therapies that are widely applicable and affordable could help to reduce the growing burden of disease. Despite lifestyle modification, cardiovascular (CV) risk factor modification, and revascularization procedures to treat severe or symptomatic manifestations of atherosclerotic disease, the burden of CV disease continues to rise, particularly in low- and middle -income countrie s. Most patients with ASCVD present with disease in a single vascular bed, but one in six have clinical evidence of involvement of more than one vascular bed. 6 million in 2019, while years lived with disability increased from 17. Worldwide cardiovascular deaths increased from 12. Further work is required to assess the possible added benefit of combining rivaroxaban with clopidogrel or ticagrelor instead of aspirin.Ītherosclerotic cardiovascular disease (ASCVD), which includes coronary artery disease (CAD), cerebrovascular disease, and peripheral arterial disease (PAD), is the leading cause of morbidity and mortality worldwide and is associated with major and rising healthcare cost s. Additional trials are underway to assess the impact of DPI therapy in other populations of interest, including patients with ACS at high risk of left ventricular thrombus formation, intracranial atherosclerotic disease with recent transient ischemic attack or stroke, peripheral arterial disease with limiting claudication or post lower extremity revascularization, and advanced chronic kidney disease with ASCVD or risk factors for ASCVD. Among patients with chronic ASCVD, those with involvement of two or more vascular beds, heart failure, chronic kidney disease, or diabetes derive the greatest absolute benefit s. Among patients with recent acute coronary syndrome (ACS), those with positive cardiac biomarkers or ST -segment elevation myocardial infarction, or a history of heart failure derive the greatest absolute benefit s. When used in combination, aspirin and low -dose rivaroxaban work synergistically to inhibit platelet activation and thrombin generation, thereby preventing thrombus formation. More recently, however, randomized trials have demonstrated the benefits and cost -effectiveness of a dual pathway inhibition (DPI) strategy in acute and chronic ASCVD. Antiplatelet therapy has long been the mainstay of antithrombotic therapy for the prevention of first -ever and recurrent ASCVD event s. Leave Your Observation Loading.Atherosclerotic cardiovascular disease (ASCVD), which includes coronary artery disease (CAD), cerebrovascular disease, and peripheral arterial disease (PAD) is associated with significant morbidity, mortality, and healthcare cost s. But this program has one drawback - it is paid. ![]() Total Commander has many additional features and capabilities. Managing files in two panels, for example, moving or copying from one folder to another, is much more convenient than in a standard file manager with one panel. Total Commander is a popular two-panel file manager for the Windows operating system. Leave Your Observation Free analogue of Total Commander ![]() Double Commander, thanks to built-in plugins, out of the box supports working with the most popular archives: zip, jar, tar, bz2, tbz, gz, tgz, Izma, tlz. If you want to know more details about it, then see the article “Free analogue of Total Commander”. What archives does Double Commander support? Double Commander is an excellent open source two-window file manager. Leave Your Observation How to add the plugin to Double Commander to support all types of archives But the method proposed in that note has disadvantages: search is slow, especially. The considered method allows you to find the required file containing the required string without installing additional programs. In the article “Full-text search for documents in a folder” we examined a way to search the contents of many office documents, including the exact match of the phrase. Leave Your Observation Full-text search in office files (Word) and archives – now it’s easy! In addition, recoll relies on pre-indexing documents, which causes problems when working with removable media: the removable media. This search and indexing of office documents can be implemented using recoll package, but it requires configuration. Unlike Windows, where “Full-text search for documents in a folder” is possible, Linux “out of the box” does not support full-text search in office formats. Tag: Double Commander Full-text search in MS Word files and archives in Linux
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